Objective To explore the application effect of mHealth intervention based on the Situation-Specific Theory of Heart Failure Self-Care in volume management of home-dwelling patients with chronic heart failure. Methods A total of 264 discharged patients with stable chronic heart failure were randomized into a control group and an experimental group, with 132 patients in each group. The control group received routine follow-up management，while the experimental group additionally received mHealth intervention based on the Situation-Specific Theory of Heart Failure Self-Care. The intervention effect was compared between the two groups. Results A total of 120 patients in the control group and 123 patients in the experimental group completed the study. Six months after the intervention, the qualified rate of dry body mass in the experimental group was higher than that in the control group （P<0.05）; the time effect, intervention effect, and time×intervention interaction effect in self-management ability between the two groups were significant(all P<0.05); and the readmission rate of the experimental group was lower than that of the control group（P<0.05）. Conclusion Application of mHealth intervention based on the Situation-Specific Theory of Heart Failure Self-Care in volume management can improve the qualified rate of dry body mass and self-care ability,and reduce the readmission rate of patients with chronic heart failure.