Objective To explore the obstacles of implementing responsibility holistic nursing among clinical nurses, so as to provide a reference for better implementation of responsibility holistic nursing. Methods A descriptive qualitative study was used to conduct semi-structured in-depth interviews among 15 clinical nurses, then content analysis was used to analyze the interview data. Results The nurses′ dilemma on implementing responsibility holistic nursing extracted five themes: the conflict between thinking mode and habit, the gap between theory and reality, the burden of writing relevant documents, the lack of nursing human resources, and the sense of burnout caused by the insignificant effect. Their suggestions were extracted two themes:a reasonable scheduling model and a sound feedback mechanism. Conclusion Nurses should overcome relevant obstacles, change traditional thinking and actively face practical obstacles when implementing responsibility holistic nursing, and administrators should optimize the allocation of human resources and promote the construction of information technology to further deepen responsibility holistic nursing.