Objective To explore effective methods to improve anxiety, depression, and quality of life in patients with dry eye. Methods A total of 92 patients with dry eye were randomly divided into the observation group and the control group, with 46 patients in each group. The control group received routine ophthalmic care, while the observation group received solution-focused brief therapy (SFBT) combined with mindfulness training psychological intervention on the basis of the control group. Before and after 8 weeks of the intervention, the Zung Self-rating Anxiety Scale, Zung Self-rating Depression Scale, Five Facet Mindfulness Questionnaire, and Short-Form 12-item Health Survey were used to evaluate the application effect. Results After the intervention, the anxiety and depression scores of the observation group were significantly lower than those of the control group, and the mindfulness and quality of life scores were significantly higher than those of the control group (all P<0.05). Conclusion SFBT combined with mindfulness training can alleviate patients′ anxiety and depression in patients with dry eye, as well as enhance their mindfulness and quality of life.