Objective To explore the effect of positive self-disclosure intervention on benefit finding, caregiving burden and quality of life of caregivers with young and middle-aged stroke patients. Methods A total of 78 caregivers with young and middle-aged stroke patients were divided into the control group and the intervention group, with 39 cases in each group. The control group received routine nursing care, and the intervention group received positive self-disclosure intervention for four weeks, a total of eight times, based on routine nursing care. The scores of benefit finding, caregiving burden, and quality of life were compared at the baseline, after the intervention instantly, one month and three months after the intervention.Results There were 36 caregivers in each group completed the study. After the intervention instantly and one month after the intervention, benefit finding score of caregivers in the intervention group was higher than that of the control group (all P＜0.05). After the intervention instantly, one month and three months after the intervention, the caregiving burden score of the intervention group was significantly lower than that of the control group, and the quality of life was significantly higher than that of the control group (all P<0.05). Conclusion Positive self-disclosure intervention can effectively promote the benefit finding, reduce caregiving burden, and improve the quality of life of caregivers with young and middle-aged stroke patients.