Objective To construct and evaluate a pediatric nurse-patient communication teaching model based on the SEGUE framework. Methods A structured pediatric nurse-patient communication teaching model was designed, including five stages: set the stage, elicit information, give information, understand the patient′s perspective, and end the encounter and theoretical study, case analysis, scenario simulation and clinical practice were used in the teaching process. A total of 98 nursing undergraduates in Grade 2018 and 2019 (experimental group) received the communication teaching practice using theoretical learning, case analysis, situational simulation, clinical practice, etc. Teaching effectiveness was compared with 55 nursing undergraduates in 2016 (control group) who were taught using conventional methods. The Harvard Medical School Communication Scale and American Association of Internal Medicine Patient Satisfaction Scale were used for evaluation. Results The total scores of clinical communication ability and standardized patient satisfaction in the experimental group were higher than those in the control group (P<0.05). Conclusion The pediatric nurse-patient communication teaching model based on the SEGUE framework is beneficial for improving students′ clinical communication abilities and improving their communication effectiveness.