Objective To summarize the best evidence related to the assessment, prevention and management of occupational contact dermatitis (OCD), and to provide a reference for the management of OCD. Methods China National Knowledge Network, Wanfang, VIP, Medlive, JBI Evidence Summary Database, the World Health Organization （WHO）, UpToDate, BMJ Best Practice, the National Institute for Health and Clinical Excellence （NICE）, the Scottish Intercollegiate Guidelines Network （SIGN）, the Guidelines International Network （GIN）, the Netherlands Centre for Evidence-based Management （CEBMa） and PubMed were systematically searched using computer, from the establishment of the database to 10 February 2023, for evidence related to management of OCD, including clinical decisions, guidelines, systematic reviews, summaries of evidence, expert consensus, and randomized controlled trials. Results A total of 16 literatures were included, consisting of 3 clinical decisions, 6 guidelines, 6 systematic reviews and 1 randomized controlled trial.The evidence was summarized from the four aspects of evaluation, protective measures, OCD treatment measures and education and training, and 33 pieces of best evidence were formed. Conclusion Summary of the best evidence for the management of OCD, can provide evidence for standardized management of OCD.It is recommended that medical staff take the actual situation into consideration and reasonably apply the evidence to prevent the occurrence or slow the progression of OCD.