Objective To explore the effect of nasal prongs and nasal mask alternately for 2h and 4h on reducing nasal pressure injury in premature infants undergoing Nasal Continuous Positive Airway Pressure (NCPAP), and to provide a reference for preventing device related pressure injury in premature infants. Methods A total of seventy-three premature infants were randomly divided into a Q2h rotation group (n=37) of nasal mask with nasal prongs and Q4h rotation group (n=36).The NCPAP use time, oxygen concentration, severity of nasal pressure injury and workload of nurses between the two groups were compared. Results There weren′t significant differences between the two groups in the incidence of nasal pressure injury, NCPAP use time and oxygen concentration （all P＞0.05）, while the nurse workload of the Q4h rotation group was significantly lower than that of the Q2h group （P＜0.05）. Conclusion The replacement of nasal prongs and nasal mask Q4h during the use of NCPAP, can improve children′s outcome of nasal pressure injury, enhance their level of comfort and safety, and reduce the workload of nursing staff at the same time.