Objective To explore the effect of multisensory intervention mode on emergence agitation during the recovery period in children receiving strabismus surgery under general anesthesia. Methods A total of 70 children receiving strabismus surgery under general anesthesia were randomized into a control group and an intervention group, with 35 cases in each group.The control group was given routine care during the emergence period, while the intervention group additionally received multisensory intervention.The incidence of emergence agitation （EA）, pain scores （FLACC）, adverse reactions during the emergence period, the length of stay in post-anesthesia unit （PACU） and the time required for bispectral index （BIS） ＞60, 70, and 80 were compared between the two groups. Results The incidence of EA, severity of postoperative pain and the incidence of dressing coming off in the intervention group were significantly lower than those in the control group, and the time required for BIS ＞80 and the length of stay in PACU were shorter than those of the control group （all P＜0.05）. Conclusion As a comprehensive, simple and easy-to-operate intervention mode, multisensory intervention can reduce the incidence of EA during the emergence period in children undergoing strabismus surgery under general anesthesia, alleviate their postoperative pain, decrease the incidence of adverse reactions, and finally improve the nursing quality of recovery period.