Objective To explore the relationships among nursing pressure, emotion disorder and cooperation support in ICU nurses, and to observe the chain mediating effect of cooperation support in nursing pressure and anxiety and depression, so as to provide a reference for conducting targeted management for ICU nurses. Methods A total of 179 ICU nurses were recruited using convenience sampling, then they were investigated by utilizing the ICU Nursing Pressure Questionnaire, the Nursing Cooperation Support Questionnaire, and the Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS). Results The ICU nursing pressure was positively correlated with depression and anxiety (r=0.200,0.238,both P＜0.05), and negatively related to nursing cooperation support (r=-0.229,P＜0.05).The nursing cooperation support was negatively correlated with depression and anxiety (r=-0.381,-0.418,both P＜0.05).Technological support-emotional support played complete chain mediating role between nursing pressure and depression (effect size was 0.049, explained 35.00% of the total effect), and the effect also exsited between nursing pressure and anxiety (effect size was 0.080, accounted for 36.90% of the total effect). Conclusion The technological support-emotional support path buffers the negative effect of nursing pressure on depression and anxiety, so nurses′ depression and anxiety can be alleviated via enhancing their technological support-emotional support.