Objective To explore the effect of management on medication discrepancy in elderly patients with coronary heart disease (CAD) during the transition from hospital to home. Methods Totally, 71 elderly CAD patients were divided into a control group (n=35) and an observation group (n=36) according to the ward where they stayed. The control group was given routine care, while the observation group additionally received management for medication discrepancy. Results The incidence of medication discrepancy in the observation group was significantly lower than that in the control group after the intervention(all P<0.05). The scores of medication literacy and medication adherence in the observation group were significantly higher than those in the control group after 8 weeks of intervention (both P<0.05). Conclusion Management for medication discrepancy can reduce medication discrepancy rate during the transition from hospital to home, and improve patients′ medication literacy and adherence.