Objective To improve the efficiency and accuracy of fall risk assessment in inpatients. Methods Patients admitted from February to December 2021 were treated as the control group and those from January to November 2022 as the study group. The control group was given routine fall risk assessment and preventive measures, while the study group received assessment and interventions by using a patient profile that was designed based on patients′ fall risk factors. A total of 305 patients in the control group and 308 in the study group were selected to compare the intervention effect. Results The incidence of falls was significantly reduced after application of the patient profile (RR=0.45,95%CI:0.36,0.65). The accuracy rate of fall risk assessment, the implementation rate of fall prevention measures and the rate of patients′ awareness of fall risk in the study group were significantly higher than those in the control group (all P<0.05). Conclusion Application of the patient profile for fall risk assessment is helpful for nurses to make a quick and accurate assessment of fall risk, so as to effectively prevent falls and ensure patient safety.