Objective To evaluate the impact of CUSP on the safety of using hip prostheses in total hip arthroplasty. Methods A total of 49 operating room nurses working in orthopedic surgery rooms were divided into a control group (n=24) and an experimental group (n=25). The control group was given standard safety management, while their counterparts in the experimental group received CUSP implementation for use of hip prostheses. After three months of intervention, the knowledge of use of hip prostheses and safety attitude were compared between the two groups. Three hundred and twenty patients who received care in each group were selected to compare the incidence of actual errors/prevented errors. Results The knowledge of use of hip prostheses and safety attitudes in the experimental group were significantly higher than those in the control group (both P<0.05), and the incidence of actual errors/prevented errors was significantly lower in the experimental group than that in the control group (P<0.05). Conclusion Implementing CUSP can create safety climate and improve the safety of use of hip prostheses.