Objective To explore the status quo of decision regret in family members of patients on continuous renal replacement therapy (CRRT) and analyze its influencing factors，so as to provide reference for targeted intervention. Methods Totally, 102 family members of patients undergoing CRRT completed a battery of questionnaires, including a general information questionnaire, the Decision Regret Scale, Control Preferences Scale, Decisional Conflict Scale and Preparation for Decision Making Scale. Results The sample scored 36.86 ±13.98 on decision regret, among whom 83.35% had a high level of decision regret. Of the 102 participants, 78 preferred a passive role, 14 preferred an active role, and 10 preferred to share responsibility with the doctor. The preparation for decision making score was 51.57±15.43, and the decisional conflict score was 27.63±9.47. Decision regret was positively correlated with decisional conflict, whereas inversely correlated with preparation for decision making (both P＜0.05). Multiple linear regression analysis showed that sex, caregiving experience, CRRT knowledge, control preferences and preparation for decision making were factors influencing decision regret of family members (all P＜0.05). Conclusion Decision regret in family members of patients undergoing CRRT is at a relatively high level and influenced by various factors. Interventions should be provided for those who are male, lack knowledge about CRRT, prefer a passive role in decision-making, or who are not well prepared for decision-making, to reduce their decision regret.