Objective To analyse the current status of affiliate stigma among caregivers of preschoolers with autism spectrum disorder (ASD) and its correlation with benefit finding and psychological resilience. Methods A total of 258 caregivers of ASD preschoolers were surveyed by using the demographic questionnaire, the Affiliate Stigma Scale (ASS), the Benefit Finding Scale (BFS) and the Connor-Davidson Resilience Scale (CD-RISC). Results The caregivers of ASD preschoolers scored （2.44±0.46） points in affiliate stigma, with the affective dimension scoring the highest and the top 5 items with the highest scores being exclusively from the affective dimension.Benefit finding and psychological resilience total scores were negatively correlated with affiliate stigma dimension scores and total scores (all P＜0.05).Hierarchical regression analysis showed that affiliate stigma among caregivers of ASD preschoolers was mainly affected by employment status, marital relationship, severity of ASD and psychological resilience; after controlling for general information of caregivers and children, benefit finding did not affect affiliate stigma among caregivers, while psychological resilience could explain 8% of the total variability of affiliate stigma (P＜0.05). Conclusion Caregivers of ASD preschoolers had a high level of affiliate stigma with the affective dimension being the most severe.Medical staff should pay attention to the psycholo-gical feelings of caregivers, take measures to improve their psychological resilience, and guide them to face difficulties with a positive attitude, so as to reduce their affiliate stigma.