Objective To explore the effect of applying case scenario simulation based on BOPPPS model in first aid training. Methods A quasi-experimental study design was adopted, and 60 clinical nurses in 2019 were selected as the control group.Traditional teaching methods including classroom teaching, skill demonstration and three-person training were used in the control group.A total of 60 clinical nurses in 2021 were selected as the experimental group, and the participative BOPPPS model based case scenario simulation teaching mode, which included such processes as introduction, targets, pre-test, participation learning, post-test and summary, was used to carry out the teaching practice of three-person first aid training. Results The skill test scores and teamwork scores of the experimental group were significantly higher than those of the control group (all P＜0.05). Conclusion The application of case scenario simulation method based on BOPPPS model can improve the first-aid skills of nurses and the effect of three-person first aid cooperation.