Objective To retrieve, evaluate and integrate relevant evidence related to the practice of nasal lavage care for patients with chronic sinusitis, and to provide a basis for the establishment of nasal lavage nursing practice standards. Methods According to the“6S”model, we searched websites/databases for all evidence on the nursing practice of nasal irrigation in chronic sinusitis patients, including clinical decision supports, evidence summaries, guidelines, expert consensus reports and systematic reviews.The publication date of the literature was limited to the period from January 1, 2017. to March 20, 2022. Results A total of 11 articles were included, including 2 clinical decision supports, 3 guidelines, 2 expert consensus reports and 4 systematic reviews.Finally, 25 pieces of best evidence were summarized into 8 aspects （preparation before operation, solution selection, volume and pressure, temperature and posture, timing and frequency, prevention of infection, special populations, precautions）. Conclusion The summarizes best evidence on nursing practice of nasal lavage care for chronic sinusitis patients, can provide an evidence-based basis for standardizing the relevant practice by nursing staff, and for the improvement in nursing effectiveness.