Objective To establish and verify a nomogram model for predicting the risk of emergence agitation in children after general anesthesia and provide a clinical assessment tool for the identification of children at high risk of agitation. Methods A total of 651 children aged 1-6 years receiving surgery under general anesthesia were enrolled and randomly divided into a derivative group (n=459) and a validation group (n=192).Based on multivariate regression analysis, we analyzed the independent predictors of emergence agitation after general anesthesia in children, and built a nomogram prediction model, which were further tested by using the 2 groups′ data. Results A total of 160 cases (113 in the derivative group and 47 in the validation group) were found to have emergence agitation, and emergence agitation rate was 24.58%.Multivariate logistic regression results showed that age, surgery departments, physical restraint, anesthesia method, analgesia therapy, and indwelling urethral catheter were predictors of emergence agitation after general anesthesia in children (all P＜0.05).A nomogram prediction model was constructed based on the predictors mentioned above.The calibration curves showed that the accuracy of the model was good.ROC curve analysis showed that AUC value was 0.767 in the derivative group, and 0.827 in the validation group. Conclusion The nomogram model for predicting the risk of emergence agitation in children after general anesthesia has good accuracy and discrimination, and can provide an evaluation tool for clinical screening of high-risk children.