Objective To describe the level and determinants of moral resilience of ICU nurses and to provide reference for the formulation of targeted training programs. Methods A convenient sample of 322 ICU nurses from three tertiary hospitals in Zhengzhou was recruited and surveyed using a demographic questionnaire, the Rushton Moral Resilience Scale, the Hospital Ethical Climate Survey, and the Nurses′ Self-Concept Questionnaire. Results The average score of moral resilience among ICU nurses was 3.03 (scale mean divided by number of items) with a standard deviation of 0.50.The total moral resilience score was positively correlated with the total scores of hospital ethical climate and nurses′ self-concept （both P＜0.05）.Multiple linear stepwise regression showed that years of ICU work, previous training experience regarding ethics, hospital ethical climate, and professional self-concept were factors affecting moral resilience among ICU nurses （all P＜0.05）, explaining 49.6% of the total variance. Conclusion Moral resilience of ICU nurses is at moderate to high level.Nursing managers need to pay more attention to nurses with lower job tenure, create hospital ethical climate, enhance nurses′ professional self-concept, and develop targeted training programs to enhance moral resilience of ICU nurses.