Objective To explore the effects of hospital-to-home nutrition management based on Internet platform on nutritional status and quality of life of patients with colorectal cancer receiving chemotherapy. Methods Totally, 74 patients with colorectal cancer receiving chemotherapy were divided into two groups according to the wards where they were treated, with 37 in each group.The control group received conventional nutrition management, while the intervention group received hospital-to-home nutrition ma-nagement using Internet platform. Results After 3 cycles of chemotherapy, objective nutritional parameters, Patient-Generated Subjective Global Assessment (PG-SGA) score, quality of life score, patient satisfaction and compliance with nutrition management in the intervention group were significantly higher than those in the control group (all P＜0.05). Conclusion Implementation of hospital-to-home nutrition management based on Internet platform is beneficial to improve nutritional status, quality of life and satisfaction of colorectal cancer patients treated with chemotherapy.