Objective To develop an intervention program to improve discharge readiness in stoma patients and to verify its effect. Methods Based on previous investigation, literature review, group discussion, expert consultation and pilot study, the intervention scheme was developed.Through a quasi-experimental research design, 43 colorectal cancer patients with stoma hospitalized in one unit were assigned to a control group, receiving standard care, while 44 hospitalized in another unit were assigned to an intervention group, which received additional interventions focused on readiness for discharge. Results The readiness for discharge, self-management ability and adaptation to stoma in the intervention group were significantly higher than those in the control group (all P＜0.05). Conclusion Interventions focused on readiness for discharge can improve patients′ discharge readiness, self-management ability and adaptation to stoma.