Objective To search for and summarize the best evidence on palliative management of psychological distress in patients with advanced cancer, and to provide evidence-based evidence for clinical intervention. Methods The publications published during January 2010 to November 2022 on palliative management of psychological distress in patients with advanced cancer, were retrieved from UpToDate, BMJ Best Practice, Cochrane Library, International Guideline Collaboration, National Hospice and Palliative Care Alliance, PubMed, CNKI, Wanfang Data, etc. Two reviewers independently evaluated the quality of the literature and extracted evidence, and worked in partnership with an evidence-based team to check and integrate the evidence. Results Twenty publications were included: 8 guidelines, 2 clinical decision reports,1 best practice report, 2 evidence summary reports, 4 systematic reviews, and 3 randomized controlled trials.The best evidence was summarized into 8 aspects totaling 24 pieces of evidence:management principles, screening and evaluation, timing of interventional management, environmental management, pharmacological intervention, non-pharmacological intervention, health education, and training and guarantee. Conclusion The summarized best evidence of palliative care management of psychological distress in patients with advanced cancer, can provide an evidence-based basis for medical workers to take preventive measures or provide care for psychological distress in this population.In clinical application, it is necessary to conform to the actual clinical situation and fully consider the needs and wishes of patients and their families to formulate scientific and individualized psychological distress management programs, in an effort to improve the quality of life of end-stage cancer patients.