Objective To implement the case manager-led care program for diabetic foot ulcer patients, and to improve care results of diabetic foot ulcers. Methods Wound therapists were selected as case managers, who worked in tandem with a multidisciplinary team consisting of wound therapists, rehabilitation therapists, orthopedic nurses and diabetes nurses, to carry out case management for 146 hospitalized patients with diabetic foot ulcers. Results None of the 146 patients had new foot ulcers, and Wagner′s score at 6 months after discharge was significantly improved compared with that before intervention （P＜0.05）.Fasting blood glucose and glycosylated hemoglobin levels were significantly decreased 6 months after discharge compared with those before discharge （all P＜0.05）.The scores of self-management activities, knowledge of foot care and behavior of patients after discharge were significantly higher than those at admission （all P＜0.05）. Conclusion The implementation of case manager-led care program can effectively improve self-management activities of patients with diabetic foot ulcers, change their knowledge and behavior of foot care, effectively control blood sugar, and promote wound healing.