Objective To explore the construction and optimization of a nursing human resources deployment management model in general hospitals, and to evaluate its implementation effect. Methods Under the three-level vertical management system, we established and optimized a nursing human resources deployment and management model, implemented tidal deployment and regional mobility management.The nursing human resources allocation and changes of nursing human resources management quality before and after the optimization were measured to evaluate the effects. Results Under the optimized deployment management model, 2 937 times of nurses were dynamically deployed in 2021, including 1 296 times of nurses for regular deployment and 1 641 times of nurses for emergency deployment.After the optimization, the overall quality of nursing human resources management and the dimension scores of dynamic deployment and flexible shift were significantly higher than those before the optimization （all P＜0.05). Conclusion The optimization of the nursing human resources deployment and management model is conducive to rational utilization and timely deployment of nursing human resources, and improving its management efficacy.