Objective To develop a Post Percutaneous Coronary Intervention Health Literacy Scale, and to test its reliability and validity, so as to provide a tool measuring health literacy for patients after percutaneous coronary intervention （PCI）. Methods Based on Netbeam health literacy theory, similar scales were referred to, and a pre-scale was developed after semi-structured interviews and a 2-round expert consultation.Then the pre-scale was used to investigate 310 patients after PCI, and item analysis, correlation analysis, reliability analysis and validity analysis were conducted to adjust its items, and to form a final scale. Results The final scale consisted of 3 dimensions, functional health literacy, communicative health literacy, critical health literacy, which included 27 items.The scale content validity index was 0.879, its item content validity index was 0.803-1.000.The Cronbach′s α coefficient of the scale was 0.824, which ranged from 0.740 to 0.886 for each dimension.The test-retest reliability of the scale was 0.841，which was from 0.627 to 0.827 for each dimension.Three common factors were extracted by exploratory factor analysis, and the cumulative variance contribution rate was 68.109%.The results of confirmatory factor analysis indicated that, χ2/df=2.004,RMSEA=0.052,IFI=0.942,TLI=0.912,CFI=0.909, all met model adaptation standard. Conclusion The Post Percutaneous Coronary Intervention Health Literacy Scale has good reliability and validity, so it can be used to measure health literacy for patients after PCI.