Objective To explore the compression effect of three cuff compression methods on forearm hematoma in elderly patients with acute coronary syndrome （ACS） undergoing interventional therapy. Methods A total of 195 elderly ACS patients with forearm hematoma after interventional therapy were divided into 3 groups chronologically, 65 cases in each group.At first, smart electronic sphygmomanometer was used to measure the blood pressure at swelling and brachial artery in the experimental group A and B, and mercury sphygmomanometer was used to measure the blood pressure at brachial artery in the control group.Then, the cuff inflatable pressure was 30 mmHg higher than the measured systolic blood pressure, and the exhaust pressure was the measured diastolic blood pressure to compress the hematoma in the three groups.The swelling and overflow of the hands, pain score, fingertip skin temperature, nurse workload, arm circumference at the end of compression and 1 hour after the end of compression, and the incidence of secondary compression were compared among the three groups. Results Among the three groups, there weren′t significant differences in hand swelling andoverflow, pain score and fingertip skin temperature （all P＞0.05）, while there were significant differences in nurse workload, arm circumference after the intervention, and the incidence of secondary compression （all P＜0.05）. Conclusion The smart electronic sphygmomanometer can compress the hematoma according to the blood pressure at the swelling, which can reduce the workload of nurses and improve the compression effect.