Medical adhesive-related skin injury (MARSI) at PICC placement site is related to the selection of PICC insertion site, the usage of different kinds of antiseptics, the type of catheter fixation device and its replacement interval.Its management mea-sures include scientific and reasonable application of dressing, the use of skin protector and adhesive remover, early identification of high risk population of skin tears and systematic management of damaged skin. It is proposed to deeply explore the mechanism of MARSI at the PICC placement site, comprehensively consider the risk factors of skin injury, establish a systematic skin management procedure, and provide targeted treatment to ensure the normal function of the catheter, so as to keep patients safe and ensure their quality of life.