Objective To explore the application effect of airflow shock vibration combined with three-way negative pressure technology in thrombolysis for PICC blockage. Methods A total of 87 patients with complete blockage of PICC catheter admitting into PICC maintenance outpatient were divided into a control group (36 cases) and an experimental group (51 cases) chronologically.In the control group, the three-way negative pressure technology was used for thrombolysis, while airflow shock vibration combined with three-way negative pressure technology was utilized for thrombolysis in the experimental group.In the two groups, the longest duration of thrombolysis was 4 hours in a single day, the remaining cavity of PICC was sealed with urokinase diluent for those failed, and thrombolysis was conducted for 4 hours on the second day, for the patients who still failed, their physicians in charge were reported for other treatment.The success rate of single-day thrombolysis, total success rate of thrombolysis and duration of successful thrombolysis were compared between the two groups. Results The success rate of single-day thrombolysis and total success rate of thrombolysis in the experimental group were significantly higher than those in the control group, and its duration of successful thrombolysis was significantly shorter than that in the control group （all P＜0.05）. Conclusion Application of airflow shock vibration combined with three-way negative pressure technology in PICC blockage, can improve the success rate of thrombolysis and shorten the duration of thrombolysis.