Objective To evaluate work engagement and its determinants in operating room specialist nurses, and to provide reference for targeted intervention. Methods A total of 641 operating room specialist nurses from 16 tertiary hospitals in Sichuan province were surveyed by using a demographic data questionnaire,the Specialty Nurse Work Engagement Scale, Three-Dimensional Inventory of Character Strengths, the Clinical Nursing Staff Information Literacy Self-rating Scale and the Job Crafting Scale. Results The participants scored 134.54±7.72 on work engagement. Multiple linear regression analysis showed that liking or disliking their sub-specialty, professional title, health status, character strengths, information literacy, and job crafting were determinants of work engagement （all P<0.05）. Conclusion Operating room specialist nurses reported moderate to high work engagement. Nursing managers should pay more attention to those with junior title, disliking the sub-specialty, with low character strengths and poor health, and enhance their information literacy and job crafting, thus to promote their work engagement.