Objective To improve the effect of ideological and political education in the course of Introduction to Nursing for undergraduate nursing students. Methods An immersion learning course, Introduction to Nursing, was developed and offered to 198 undergraduate nursing students in the second semester. Ideological and political education was integrated in this semester-long course, method for evaluating teaching effect was reformed, and teaching contents and objectives were established. Results Students had significantly higher course grades than the controls (n=306) who enrolled in the previous year (P<0.05). Their comprehensive performance met the requirements of the teaching syllabus, and the scores of self-efficacy and professional identity were significantly enhanced after the teaching (both P<0.05). Conclusion The integration of ideological and political education with various ideological and political elements for immersion learning of the course of Introduction to Nursing, enriches pedagogical method and improves teaching effect of ideological and political education.