Objective To improve the effect of ideological and political education in the curriculum of life and death education. Methods The teaching scheme of ideological and political education in life and death education curriculum was designed based on the concept of "adapting to the events, advancing with the times, and updating according to the situation", and 90 undergraduate medical students enrolled in this course participated in the teaching.The life attitude of the students before and after the curriculum was compared, and students′ evaluation on the course was collected after the curriculum. Results After the curriculum, the total score of life attitude and four dimensions of life meaning, life control, suffering acceptance and death acceptance of students were significantly higher than those before the curriculum (all P＜0.05).In the course evaluation, 96.67% of students thought that the teaching scheme of ideological and political education in the life and death education curriculum was in line with the cognitive law and acceptance characteristics, 90.00% of students thought that it met their psychological needs and ideological expectations, 95.56% of students thought that the gains were great, and 92.22% of students were satisfied with the course. Conclusion The ideological and political teaching in life and death education curriculum based on the concept of "three causes" is conducive to improve students′ life attitude and ideological and political literacy.Students have a higher overall sense of benefit and satisfactory teaching effects.