Objective To comprehensively evaluate the effects of non-pharmacological interventions on postoperative delirium in patients undergoing cardiovascular surgery, and to provide reference for selecting the best intervention measures. Methods Chinese Biomedical Literature Service System, China National Knowledge Infrastructure （CNKI）, Wanfang Database, VIP database, PubMed, Web of Science, Cochrane Library, Embase and Scopus were searched from the establishment of the database to March 2022.Randomised controlled studies of the effects of different non-pharmacological interventions on postoperative delirium in patients undergoing cardiovascular surgery were retrieved.Two researchers independently screened the literatures, extracted the data, and evaluated the literature quality.Stata 16.0 software was used for network meta-analysis. Results Sixteen studies were included, with a total sample size of 2 011.The results of network meta-analysis showed that targeted psychological intervention （OR=10.15，P＜0.05） had the best effect on prevention and treatment of postoperative delirium, followed by early activity, music therapy, ABCDE bundle nursing measures, targeted sedation analgesia combined with early activity （OR=3.48-5.42，P＜0.05 for all）. Conclusion Targeted psychological intervention and early exercise are the best multi-component and single non-pharmacological intervention measures, respectively.Multicomponent non-pharmacological interventions have advantages over single interventions for the prevention of postoperative delirium in patients undergoing cardiovascular surgery.In the future, a multi-component non-pharmacological intervention program with precise strategy can be developed based on evidence-based evidence to reduce the incidence of postoperative delirium.