Objective To reduce the negative mood of patients with malignant tumors undergoing concurrent chemoradiotherapy, and increase their post-traumatic growth level. Methods A total of 140 patients with malignant tumors admitted to the radiotherapy department for concurrent chemoradiotherapy were divided into intervention group (73 cases) and control group (67 cases) according to the inpatient wards.The control group received routine nursing, while the intervention group received spiritual care interventions on the basis of routine nursing.The effects of the intervention were evaluated by measuring the level of patient′s anxiety, depression, and post-traumatic growth before the intervention, one month and three months after the end of the intervention, respectively. Results A total of 72 cases in the intervention group and 64 cases in the control group completed this study. Three months after the end of the intervention, the scores of anxiety and depression in the intervention group were significantly lower than those in the control group, and the post-traumatic growth score was significantly higher than that in the control group (all P＜ 0.05). Conclusion Spiritual care can enable patients with malignant tumors undergoing concurrent chemoradiotherapy to seek transcendence and growth in adversity, improve negative emotions, and promote mental health.