Abstract: Objective To relieve the anxiety, depression and self-perceived burden of young and middle-aged patients with inflammatory bowel disease（IBD）. Methods According to the admission time, 68 young and middle-aged IBD patients were divided into control group and intervention group, with 34 cases each.The control group received routine care, while the intervention group received the Problem Management Plus (PM+) intervention on the basis of the control group.The effect of the intervention was evaluated one month and three months after the end of the intervention. Results The scores of anxiety, depression and self-perceived burden in the intervention group were significantly lower than those in the control group one month and three months after the end of the intervention (all P＜0.05). There were statistically significant differences in group, time and group-by-time effects (all P＜0.05). Conclusion The Problem Management Plus (PM+) intervention can relieve the self-perceived burden, anxiety and depression of young and middle-aged IBD patients, and improve their mental health.