Objective To explore the effect of applying a lower limb intelligent weight-bearing rehabilitation robot in rehabilitation training of patients receiving anterior cruciate ligament reconstruction. Methods Ninety-six patients were evenly divided according to either of the 2 periods they were admitted. The control group received conventional rehabilitation training, while the intervention group used a lower limb intelligent weight-bearing rehabilitation robot to assist in training. The intervention effect was compared between the two groups. Results The intervention group had better range of motion of the knee joint and knee function scores, lower pain scores, and higher activities of daily living scores, than the control group (all P<0.05). Conclusion Application of the intelligent weight-bearing rehabilitation robot in rehabilitation training of patients receiving anterior cruciate ligament reconstruction can improve the function of the knee joint, reduce pain level in training and improve activities of daily living of patients.