Objective To understand the current situation and influencing factors of clinical nurses′ knowledge, attitude and practice towards enteral nutrition related diarrhea,so as to provide a reference for clinic conducting related training and management. Methods A total of 1444 clinical nurses were investigated by utilizing a self-designed general information questionnaire, a knowledge test questionnaire and the Chinese version of the Definitions, Attitudes and Practicesin Relationto Diarrhea during Enteral Nutrition Questionnaire (DAPonDEN). Results Clinical nurses scored (21.97±2.94), (20.29±5.35), (33.17±5.10) and (55.17±17.25) on the subscale of definition, attitude, practice and knowledge towards enteral nutrition related diarrhea in DAPonDEN.Multiple linear regression analysis showed that, working years, position, professional title, frequency of enteral nutrition care and times of enteral nutrition specialized training were the influencing factors of clinical nurses′ knowledge, attitude and practice towards enteral nutrition related diarrhea (all P＜0.05). Conclusion Clinical nurses′ knowledge, attitude and practice towards enteral nutrition related diarrhea still needs to be improved. Nursing managers should improve clinical nurses′ knowledge, attitude and practice towards enteral nutrition related diarrhea based on their personal characteristics through multi-mode training.