Objective To explore dyadic coping profiles among hospitalized patients with pregnancy complications and their spouses, as well as their relationship with anxiety symptoms. Methods A total of 197 pairs of patients with pregnancy complications and their spouses were investigated using a general data questionnaire, the Dyadic Coping Inventory and the State-Trait Anxiety Inventory-State. Results The dyadic coping of patients with pregnancy complications and their spouses can be classified into four profiles:couples with low coping group (23.9%), couples with general coping group (45.2%), patients with high-spouses with low coping group (8.1%) and couples with high coping group (22.8%).The results of hierarchical logistic regression analysis showed that, after controlling for general information, the risk of positive anxiety symptoms of patients in the couples with low coping group were 12.315 times as high as that in the general coping group, while spouses in the couples with high coping group had a 67.9% lower risk of positive anxiety symptoms than that in the couples with general coping group (all P＜0.05). Conclusion Patients and their spouses in the couples with low coping group are high risk population of anxiety symptoms that need early screening and attention.Interventions for couples as a whole should be developed and implemented.