Objective To translate the Health-Related Quality of Life Inventory for Family Caregivers of Hemodialysis Patients (FCHP-QOL), and to test its reliability and validity. Methods The English version of FCHP-QOL was translated into Chinese according to Brislin′s translation model, then the Chinese version was used to investigate 738 family caregivers of hemodialysis patients to explore its reliability and validity. Results The content validity index of items of the Chinese version of FCHP-QOL ranged from 0.848 to 1.000, and which was 0.935 for the scale.Five common factors were extracted by exploratory factor analysis, containing 35 items, and the cumulative variance contribution rate was 64.172%.The model of confirmatory factor analysis had good fitness.The total Cronbach′s α coefficient of the scale was 0.831, and which ranged from 0.694 to 0.821 for the five common factors.The test-retest reliability of the scale was 0.886.The correlation coefficient between the total score of FCHP-QOL and Zarit Caregiver Burden Interview was -0.821 （P＜0.05）. Conclusion The Chinese version of FCHP-QOL has good reliability and validity.It is suitable to measure the quality of life for Chinese family caregivers of hemodialysis patients.