Objective To increase participation and effect of shared decision making in diagnosis and treatment for middle-aged lung cancer patients undergoing chemotherapy. Methods A total of 76 middle-aged lung cancer patients undergoing chemotherapy were divided into a control group and an experimental group chronologically, with 38 cases in each group.The control group was routinely informed diagnosis and treatment and cared, while the experimental group additionally received interprofessional share decision-making programme. Results After the intervention, the scores of the All Aspects of Health Literacy Scale and the Patients′ Satisfaction with Participation in Medical Decision Making in the experimental group were significantly higher than those of the control group, while its score of the Decisional Conflict Scale was significantly lower than that of the control group (all P＜0.05) . Conclusion Practice of the programme on participating in interprofessional share decision-making in middle-aged lung cancer patients undergoing chemotherapy is conducive to improving patients′ health literacy, reducing their decisional conflict, and increasing their satisfaction with participation in medical decision making.