Objective To design an inpatient companions management program which is built into the hospital information system（HIS） and examine its application effects. Methods Based on such information systems as the internet hospital system, the hospital smart system, etc., an inpatient companions management program was constructed， which included such modules as epidemiological history investigation, application for free nucleic acid test, application for electronic identification (ID) card, temperature monitoring and registration, and reporting as well as statistic query. The program was connected with the hospital smart nursing system before it was put into use across the hospital. The qualified rate of one patient one companion policy, the qualified rate of valid electronic companion ID card, the qualified rate of daily temperature monitoring and reporting, the rate of traceable electronic ID card, the average time spent on epidemic control formalities by nurses and managers and the satisfaction of nurses and managers with the program were compared before and after implementation of the inpatient companions management program. Results After implementation of the inpatient companions management program, the qualified rate of one patient one companion policy, the qualified rate of valid electronic ID card, the qualified rate of daily temperature monitoring and reporting, the rate of traceable electronic ID card, saw significant improvement from before (all P＜0.05）. The average time spent on patient companion management by nurses dropped from （554.13±30.77）s to （311.67±21.54）s (P＜0.05）. The satisfaction of nurses and managers with the program saw significant improvement from before (all P＜0.05）. Conclusion The inpatient companions management program can effectively improve the quality and efficiency of inpatient companions management, and increase the satisfaction of frontline nurses and managers.