Objective To explore the effect of applying information technology based closed-loop management model in management of high-value and low-value consumables in the operating room. Methods Using historical control design, 36 737 operations from May to December 2019 were seen as the control group, whose consumables were managed with an information system which was still in need of manual work. Another 31 710 operations from May to December 2020 were seen as the intervention group, whose consumables were managed with information technology based closed-loop management model. The clinical application effects of the two methods were compared. Results The intervention group had shorter time spent on price charging of high-value consumables, lower error rate and omission rate, higher accuracy rate of low value consumables, lower inventory occupancy rate, and higher nurse satisfaction rate, than the control group (all P<0.05). Conclusion Information technology based closed-loop management model could improve efficiency and accuracy of management, and draw praises and approval from operating room nurses.