Objective To explore the levels and relationship of stigma and quality of life among lymphoma patients. Methods One hundred and twenty patients with lymphoma were surveyed by using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 health-related quality of life questionnaire and the Social Impact Scale. Results The total score of stigma was 61.07±10.37 and the golbal health/quality of life score was 55.07±22.46.Multiple linear regression analysis showed that the extent of communication with medical staff and stigma were the factors that affected patients′ quality of life （both P＜0.05）. Conclusion Lymphoma patients report lower quality of life and higher stigma.Stigma is negatively correlated with quality of life.Medical staff should identify patients with high stigma as early as possible and take targeted measures to improve their quality of life.