Objective To explore the impact of resourcefulness on second victim experience and support of emergency department (ED) nurses. Methods A total of 419 ED nurses from six tertiary general hospitals in Changsha city were invited to fill out the Se-cond Victim Experience and Support Tool and the Resourcefulness Scale. Results The sample scored （85.21±12.66） on resourcefulness and （65.25±11.27） on second victim experience and support respectively, showing significant negative correlation between them (P＜0.05).Resourcefulness could explain 10.8% of the total variance for second victim experience and support. Conclusion The higher the resourcefulness of ED nurses, the smaller impact of second victim experience and support.Nursing managers should take effective measures to improve the resourcefulness of ED nurses and to reduce their negative emotions after patient safety incidents.