Objective To describe the fertility quality of life (QoL) of men with non-obstructive azoospermia (NOA) and to explore the influencing factors. Methods The sample consisted of 311 men with NOA who were under treatment in the infertility center.A general information questionnaire, the Chinese version of the Fertility Quality of Life （FertiQoL） and Social Support Rating Scale （SSRS） were used to analyze the fertility QoL and related factors of NOA patients. Results The total FertiQol score of NOA patients was 65.55±13.52.The results of multivariate regression analysis showed that years of infertility, annual household income, the number of assisted reproductive treatment cycles and social support were the main factors that influenced the fertility QoL of NOA patients, explaining 35.4% of the total variance. Conclusion NOA patients′ fertility QoL is relatively poor.Medical staff should pay attention to those with long years of infertility, low family income, more assisted reproductive treatment cycles and low social support, and take corresponding interventions to improve their QoL.