Objective To systematically review the prevalence and risk factors for frailty in elderly patients with chronic obstructive pulmonary disease (COPD). Methods We searched electronic bibliographic databases for eligible original studies published from 2000 to February 2022. Studies reporting on the prevalence and risk factors for frailty in elderly COPD patients were included.Two reviewers independently screened literature, appraised the study methodological quality, extracted data, then performed meta-ana-lysis using Stata12.0 and RevMan5.3. Results Twenty-six studies met the inclusion criteria, comprising 6,849 participants.The pooled prevalence of frailty in COPD patients was 34%.The main risk factors for frailty were age （OR=1.15）, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages （OR=3.00）, modified Medical Research Council (mMRC) dyspnea score （OR=3.44）, depression （OR=3.36）, comorbidity （OR=3.39）, polypharmacy （OR=4.09）, and malnutrition （OR=5.79）. Conclusion Frailty is highly prevalent among COPD patients and affected by many factors.Early assessment and intervention should be taken to reduce adverse outcomes.