Objective To explore the effect of using a self-invented heated inflatable fixation device in PICC placement. Methods A total of 428 patients to receive PICC placement were selected and randomly divided into 2 groups. The control group (n=224) received routine PICC placement under the guidance of ultrasonography, while the intervention group (n=204) additionally used a self-invented heated inflatable fixation device to secure the punctured arm during the procedure. Results The 1-puncture success rate, and 1-insertion success rate in the intervention group were significantly higher than those in the control group; the former group also reported less pain than the latter group (all P<0.05). The intervention group had shorter time in PICC placement, and lower incidence rates of mechanical phlebitis and catheter-related blood stream infection, than the controls (all P<0.05). Conclusion The usage of the heated inflatable fixation device improves the efficiency of PICC placement, and reduce the incidence of placement related complications.