Objective To explore the effect of a multi-sensory wake-up program in general anesthesia patients undergoing thoracic surgery. Methods The patients undergoing thoracic surgery from January to August 2021 were divided into 2 groups of 51 cases. The control group received traditional voice wake-up, while the intervention group was subjected to a multi-sensory wake-up program. The recovery time of spontaneous breathing, the length of stay in the recovery room, the degree of sore throat and agitation, and the incidence rate of mean arterial pressure (MAP) fluctuations were compared between the two groups. Results The intervention group had shorter recovery time of spontaneous breathing and length of stay in the recovery room, milder degree of sore throat and agitation, and lower incidence rate of MAP fluctuations, than the control group (all P<0.05). Conclusion The multi-sensory wake-up program，which extends beyond the original single sensory wake-up mode, shortens the wake-up time of patients after thoracic surgery, reduce the length of stay in the recovery room, and improve the quality of recovery.