Objective To decrease the incidence of intraoperatively acquired pressure injury (IAPI) in neurosurgical procedures. Me-thods A total of 1,378 patients undergoing elective neurosurgery between October and December, 2019, were treated as the control group and given routine measures for prevention of IAPI, while 1,551 patients between October and December, 2020, were served as the observation group and received multidisciplinary interventions for the management of IAPI. Results The incidence of IAPI was 0.90% in the observation group and 2.18% in the control group, showing significant difference （P＜0.05）.The curative rate of IAPI had no significant difference between the two groups (P＞0.05).The implementation rates of key monitoring indicators for IAPI prevention were satisfactory (＞88.00%) in the observation group, except for the implementation of standardized postoperative handover being 61.40%. Conclusion Multidisciplinary collaboration can effectively reduce IAPI and improve the quality of prevention and management.