Objective To reduce the incidence of intraoperative hypothermia in total knee arthroplasty （TKA） and to improve patients′ experience. Methods A total of 281 unilateral TKA patients were divided into a control group of 137 and an experimental group of 144 according to their admission time.The control group was given routine warming measures, while the experimental group received a checklist for management of hypothermia during the entire surgical process. Results The experimental group had significantly lower incidence of hypothermia and shivering, while significantly higher thermal comfort and satisfaction compared with the control group （all P＜0.05）.Nurses′ satisfaction was also significantly enhanced after implementing the checklist (P＜0.05). Conclusion The application of checklist for prevention of hypothermia in TKA can reduce hypothermia, improve patient experience during the surgery, and enhance job satisfaction of nurses.