Objective To investigate the supportive care needs and associated factors among patients after radical cystectomy during the rehabilitation stage, and to provide reference for targeted intervention. Methods A total of 238 patients underwent radical cystectomy were surveyed at postoperative 1 week, 1 month and 6 months by utilizing a self-designed questionnaire in terms of their supportive care needs. Results The scores of supportive care needs at three time points were （94.09±5.21）,（92.82±4.79）, and （90.78±5.14）, showing significant difference （P＜0.05）.Multiple linear regression showed that family income per capita, age, place of residence, and comorbidity of chronic diseases were the influencing factors of supportive care needs （all P＜0.05）. Conclusion The supportive care needs of patients after radical cystectomy show a declining trend. Healthcare workers should provide support and education for those with low income, poor physical fitness, and limited access to information, so as to meet their needs and improve quality of life.