Objective To enhance asthma control in children and their family management level. Methods We built a management team, developed an asthma-specific database comprising two modules of treatment and follow-up, included children with admissions under ICD-10 codes J45 "Asthma" and J46 "acute severe asthma", and provided doctor-nurse collaborative whole-process management. The database could be used through desktop browser (in hospital only) and WeChat public account of the hospital.The effect was evaluated in 100 children who had 6 months of management. Results After 6 months, the scores of asthma control and family management were significantly increased (both P＜0.05), and the rate of complete asthma control increased from 13.0% in the first month to 82.0% in the sixth month. Conclusion The construction of pediatric asthma-specific database and provision of doctor-nurse collaborative management can effectively improve disease management in children with asthma.